Methods of analysis

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The Physical-Chemical Department (PCD), due to highly qualified personnel and appropriate equipment, has the opportunity to conduct testing of medicines and medical products using the various pharmacopoeial methods. Methods we use in laboratory:

  • identification, quantification (assay) and impurities by high performance liquid chromatography (HPLC) using diode-matrix (DAD), multi-wavelength UV and refractometric (RID) detectors;
  • molecular weight distribution and macromolecular impurities by the method of size-exclusion chromatography,
  • identification, quantification (assay) and impurities by gas chromatography (GC) using a flame-ionization detector (PID);
  • identification, quantification (assay) and impurities by thin-layer chromatography (TLC) method using an automated applicator of the solutions;
  • identification and quantification (assay) by spectrometry methods: UV-VIS, IR, AAS;
  • identification and quantification (assay) by polarimetry;
  • assay by visual and potentiometric titration method (non-aqueous, acid-base, sedimentation, oxidation-reduction, complexometric, etc.);
  • determination of water by the semi-micro method K. Fischer;
  • measurement of relative density with high accuracy (up to 4-5 characters) and using a small sample quantity (2-5 ml) – a method of densitometry with the measurement of the characteristic frequency of oscillations);
  • measurement of viscosity (dynamic, kinematic, relative, characteristic, specific) using glass viscometers, rotational viscometer and microscopic module using the method of a falling ball;
  • pharmaco-technological tests (dissolution of solid dosage forms, disintegration of tablets, capsules, suppositories, friability, hardness);
  • conductivity and osmolarity of solutions;
  • control of visible and invisible particles

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